AI and Analysis-ready Data Data Curation and Management Data Quality Bioinformatics & Data Science

The 'O' word

Not so long ago, there was a period where we quietly stopped using the word "ontology" in sales conversations for fear it would scare people off. There was a (unwarranted imo) sense in the industry that they were too complicated, too expensive and too academic.

 

That was a few years ago, but fast forward to Gartner's Data & Analytics Summit 2026 and they're calling semantic layers "critical infrastructure" in the same breath as cybersecurity. Whaaaat. 'Semantics' and 'Ontology' are also trending on Google, as you can see. So what changed?

 

Well, a few things converged: LLMs made the value of structured knowledge more apparent (and the cost of not having it painful), large players like Palantir and Microsoft started baking ontologies into their data platforms, and the AI debt from inconsistent, unaligned data became harder to ignore.

 

But "ontology" meaning different things to different people is worth unpacking because not all ontologies are created equal.

 

The scientific community has spent decades building under the open world assumption: knowledge is incomplete and so are the ontologies that model it. That's given us rich, carefully curated resources like GO, MONDO, and ChEBI that underpin a huge amount of our biomedical research.

 

Palantir's ontology, and Microsoft's in its Fabric platform, operate under a different assumption. Closed world, closed source and optimised for enterprise data analytics. Useful, but a different beast entirely.

My concern would be that as the big platforms drive mainstream adoption of "ontology", the decades of knowledge from the open source semantics community gets set aside in favour of something closed and easier to manage and sell. That would be a shame and ultimately counterproductive for anyone trying to do serious science on top of these platforms. It will be interesting to see how that evolves.

 

I'll be talking more about this and more at the Pistoia Alliance 2026 London Conference

 

Hope to see you there!

Frequently Asked Questions

What is an ontology in data management?
An ontology is a formal, machine-readable model of a domain that defines its concepts, the properties of those concepts, and the relationships between them. Unlike a data schema, which describes how records are stored, an ontology describes what the records mean, which lets software reason over data rather than only retrieve it.
What is a semantic layer, and how is it different from an ontology?
A semantic layer is the translation tier between raw data and the people or systems querying it, mapping technical fields to business or scientific meaning. An ontology is often the knowledge model that a semantic layer is built on. In practice the terms overlap heavily in vendor marketing, so it is worth asking which sense is meant in any given conversation.
Why are ontologies and semantic layers suddenly getting attention?
Several developments converged. LLMs made the value of structured knowledge obvious and the cost of missing it painful, major platform vendors including Palantir and Microsoft began building ontology capabilities directly into their data products, and the accumulated AI debt from inconsistent, unaligned data became too expensive to ignore. Gartner's 2026 data and analytics predictions forecast that by 2030, universal semantic layers will be treated as critical infrastructure alongside data platforms and cybersecurity.
Why does it matter whether ontology standards stay open?
If mainstream adoption of the word "ontology" comes to mean only closed, vendor-controlled models, decades of community-curated scientific knowledge risk being set aside for something easier to sell and manage. That would be counterproductive for anyone attempting serious science on top of these platforms, because closed models cannot be independently inspected, extended, or aligned across organizations.
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Jane Lomax
About The Author
Jane Lomax
Ontologies | Terminologies | Data Standards | Data Modelling | Life Science | Biocuration | Professional Services | PhD
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Tags: #AI and Analysis-ready Data #Data Curation and Management #Data Quality #Bioinformatics & Data Science
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