PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors
Journal: Nature Cancer
Spatial Innovation Initiative Delivering Harmonized Analysis-Ready Datasets.
Poster: BioIT World Conference & Expo, April 2024
Integrative Approach to Data Harmonization: Empowering Biomedical Research with Rancho Biosciences' Terminology Management Solution (TMS)
Poster: BioIT World Conference & Expo, April 2024
Streamlined Flow Cytometry Data QC Through Interactive Visualization
Poster: BioIT World Conference & Expo, April 2024
Accelerating Biomedical Discovery with Public Data Single Cell Data Science Consortium Harnesses Collective Expertise to Deliver Even More High Value Harmonized Datasets in Year 3
Poster: BioIT World Conference & Expo, April 2024
Utilizing NIIMBL and ISA-88 Framework to Create a Proof of Concept Pharmaceutical Manufacturing Ontology
Poster: BioIT World Conference & Expo, April 2024
Unleashing Data’s Full Potential through Integrated Data Marts
Poster: BioIT World Conference & Expo, April 2024
A Digital Platform That Transforms Tox Safety Knowledge Into Insights
Poster: SOT 63rd Annual Meeting, March 2024
Extraction of High Content Toxicity Biomarkers Data from Scientific Literature
Poster: SOT 63rd Annual Meeting, March 2024
HDinHD: An Online Data Portal for Huntington's Disease Research
Poster: 19th Annual Huntington's Disease Therapeutics Conference, February 2024
Analysis and classification of transcriptome dysregulation signals over the course of Huntington’s disease progression in mouse model systems
Poster: 19th Annual Huntington's Disease Therapeutics Conference, February 2024
Early intervention to lower mHTT in the adult zQ175 mouse model results in superior efficacy compared to later intervention.
Poster: 19th Annual Huntington's Disease Therapeutics Conference, February 2024
Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade.
Journal: Cancer Cell March 2024
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Journal: Brain March 2024
Single Cell Data Science Consortium Enables Rapid Analysis of High Value Public Datasets
Poster: Pistoia Alliance Conference, 2023
Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness.
Journal: Biofabrication 2023
Using Artificial Intelligence to Enhance Terminology Mapping Workflow from Data Collection to Standardization.
Poster: 2023 BioTechX Conference, October 4 – 6, Basel, Switzerland
Identification and Annotation of Publicly Available Single Cell RNA-sequencing Data.
Poster: 2023 Festival of Genomics & Biodata, October 4 – 5, Boston, MA
Single Cell Data Science Consortium Enables Rapid Analysis of High Value Public Datasets.
Poster: 2023 BioTechX Conference, October 4 – 6, Basel, Switzerland
Unpacking Unstructured Data: A Pilot Study on Extracting Insights from Neuropathological Reports of Parkinson’s Disease Patients using Large Language Models
Journal: bioRxiv, September 2023
NF Research Tools Central: A disease-specific knowledgebase of experimental tools.
Poster: 2023 NF Conference, June 24–27, Fairmont Scottsdale Princess, Arizona,
Jovanovic et al., A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells.
Journal: Stem Cell Reports (2023)
Single Cell Data Science Consortium Enables Rapid Analysis of High Value Public Datasets
Poster: Bio-IT World Conference in Boston May 16-18 2023
Unpacking Unstructured Data: Large Language Models used to extract insights from Neuropathological Reports of Parkinson's Patients
Poster: Bio-IT World Conference in Boston May 16-18 2023
Using Graph Technologies and Artificial Intelligence to Power Terminology Management
Poster: Bio-IT World Conference in Boston May 16-18 2023
HDinHD: A Data Portal for Huntington's Disease Research 2023
Poster: CHDI 2023 HD Therapeutics Conference Dubrovnik, Croatia
Prediction of standard cell types and functional markers from textual descriptions of flow cytometry gating definitions using machine learning.
Journal: Wiley Clinical Cytometry 2022
Association of nuclear shape in the tumor epithelium with response to atezolizumab in NSCLC.
Publication: ASCO 2023 Annual Meeting https://meetings.asco.org/abstracts-presentations/223107
Effect of Small Molecule Splicing Modulators on proteome and transcriptome of HD stem cell derived neurons
Poster: CHDI HD Therapeutics Conference 2022
NCATS FRDB: Fast Response DataBase for Drug Repositioning
Poster: BioIT World Conference and Expo 2022
Stage-Specific Disease Genes in the Cortex and Striatum
Poster: CHDI HD Therapeutics Conference 2022
Measuring Disease Phenotype Reversal of HD Related Genomics Signatures in Response to Therapeutic and Genetic Perturbations Using Posterior Probabilities
Poster: CHDI HD Therapeutics Conference 2022
SEQUIN: rapid and reproducible analysis of RNA-seq data in R/Shiny
Journal: bioRxiv 2022
NCATS Inxight Drugs: a comprehensive and curated portal for translational research
Journal: Nucleic Acids Research 2022
PerturbDB: A Database of Huntington's Disease Perturbation Studies https://www.hdinhd.org/
Poster: CHDI HD Therapeutics Conference 2022
HDinHD: A Data Portal for Huntington's Disease Research https://www.hdinhd.org/
Poster: CHDI HD Therapeutics Conference 2022
Enhancing the Fitness of Embryoid Bodies and Organoids by Chemical Cytoprotection
Journal: bioRxiv 2022
Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures.
Journal: bioRxiv.org Preprint 2022
Mapping of UK Biobank clinical codes: Challenges and possible solutions
Journal: PLOS ONE 2022
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research
Journal: Journal of Chemical Information and Modeling 2022
SINGLE-CELL RNA-SEQ OF hPSC-DERIVED NEURAL CELL TYPES REVEALS EARLY GLIA-SPECIFIC DIFFERENTIATION TRAJECTORIES
Poster: NCATS 2022
Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model.
Publication: JCI Insight 2022
Predicting patient treatment response and resistance via single-cell transcriptomics of their tumors.
Publication: ASCO 2022 Annual Meeting https://meetings.asco.org/abstracts-presentations/207511
Mapping brain gene co expression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures
Journal: Neuron 2022
The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia
Journal:Pharmaceuticals, December 2022
Circulating microRNA associated with future relapse status in major depressive disorder
Journal: Frontiers in Psychiatry, August 2022
An automated 13.5 hour system for scalable diagnosis and acute management guidance for genetic diseases.
Journal: Nature Communications July 2022
Towards a comprehensive view of diagnoses in UK Biobank by data curation and aggregation.
Journal: Bio-IT World Conference & Expo 2021
HDinHD: A Rich Data Portal for Huntington’s Disease Research
Journal: Journal of Huntington’s Disease 2021
Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)
Poster: SITC Conference 2021
NCATS- Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis
Journal: BioRxiv 2021
Building towards a computational infrastructure to aid in the interpretation of Bicycle® toxin conjugate response profiles.
Poster: BioIT World 2021
Implementation of the FAIR Data Principles for Exploratory Biomarker Data from Clinical trials.
Journal: Data Intelligence 2021
Molecular-based enrichment strategy for Nectin-4 targeted Bicycle toxin conjugate BT8009
Poster: American Association for Cancer Research April 2021
Housekeeping genes involved in non-malignant breast phenotypes are widely expressed in multiple cancers and provide novel biomarkers of tumor classification
Journal: Brazilian Journal of Medical and Biological Research, February 2021
HD Mouse Striatum RNA and Protein Disease Signatures
Poster : CHDI Annual Conference 2021
Application of MCAT questions as a testing tool and evaluation metric for knowledge graph based reasoning systems.
Journal: Clinical and Translational Science 2021
Lung Fibrosis after COVID-19: Treatment Prospects
Journal: Pharmaceuticals, August 2021
Assessing the use of telemetric devices in preclinical safety studies in non-human primates - data aggregation step
Journal: Bio-IT World Conference & Expo 2021
Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma
Poster : Blood American Society Of Hematology 2021
HD Phenocopy Disease Share Dysregulated Genes with HD
Poster : CHDI Annual Conference 2021
Searching for Genomic Biomarkers for Major
Depressive Disorder in Peripheral Immune Cells
Journal: Biological Psychiatry 2020
An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD)
Journal: Journal of Biomedical Semantics 2020
HTT protein nomenclature: The challenge with variable domains
Poster: CHDI Conference 2020
Global Substance Registration System: consistent scientific descriptions for substances related to health
Journal: Nucleic Acids Research 2020
Gene Expression and Genomic Markers Identify a Subpopulation of Poor Prognosis t(4;14) Patients in Newly Diagnosed Multiple Myeloma.
Journal: Blood American Society Of Hematology 2019
Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease
Journal: Leukemia 2019
Large-Scale Analysis of Relapsed/Refractory Multiple Myeloma Genome Reveals Increased Prevalence of High-Risk Molecular Features and Oncogenic Drivers
Journal: Blood American Society Of Hematology 2019
Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients
Journal: Blood American Society Of Hematology 2019
The NCATS BioPlanet - an integrated platform for exploring the universe of cellular signaling pathways for toxicology, systems biology, and chemical genomics
Journal: Frontiers in Pharmacology 2019
NCATS Stitcher: Data integration and guided Curation tool
Meeting: BioIT 2019
Data deluge: challenges and solutions in implementing a precision medicine approach to create the TRACK-TBI information Commons
Meeting: BioIT 2019
Aggregation and integration of UKbiobank phenotypes data for downstream analysis
Meeting: BioIT 2019
Expression concordance of 325 novel RNA biomarkers between data generated by NanoString nCounter and Affymetrix GeneChip
Journal: Disease Markers 2019
Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control Studies
Journal: Biological Psychiatry 2019
A novel panel of 80 RNA biomarkers with differential expression in multiple human solid tumors against healthy blood samples
Journal: International Journal of Molecular Sciences 2019
A predictor of pathological complete response to neoadjuvant chemotherapy stratifies triple negative breast cancer patients with high risk of recurrence
Journal: Scientific Reports 2019
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
Journal: Blood American Society Of Hematology 2018
A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis
Journal: Leukemia 2018
Crowdsourcing a High-Risk Classifier for Multiple Myeloma Patients
Journal: Blood American Society Of Hematology 2017
Replicable and coupled changes in innate and adaptive immune gene expression into case-control studies of blood Microarrays in major depressive disorder
Journal: Biological Psychiatry 2017